PKRRATING - AN OVERVIEW

The interfacial residues are very conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations support a product where by activating RNA serves to be a scaffold to bind many read more PKR monomers, risin

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